A growing number of compounds are being withdrawn from the list of accepted ingredients of perfumes and flavors because of side effects or environmental concerns. As an example, nitro musk and polycyclic musk are about to be completely banned from the perfumer’s palette. On the other hand, the use of some compounds with a positive organoleptic profile is restricted because of production costs. Hence, there is a growing interest in finding substitutes or Enhancers. The identification of Olfactory Receptors (ORs) that mediate the perception of a compound of interest paves the way for the discovery of efficient surrogates, i.e. new compounds that activate the same receptors and will have the same organoleptic characteristics but improved properties (production cost, Intellectual Property (IP), etc.). Those receptors are also targets for Enhancer discovery programs. By lowering the perception threshold of the odorant of interest, these Enhancers will allow lower quantities to be used in finished products, enabling substantial cost savings.
|Odour type||Coumpond||Number of responding ORs|
|Nitro musk||Musk xylene||3|
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