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Screening
Agonist
ChemCom has deorphanized (i.e. identified which chemical entity can activate the receptor) many human Olfactory Receptors (hORs).
ChemCom holds confidential data on hORs that respond to a pleasant odor of interest (e.g. amber, musk, sandalwood, marine, green, floral, fruity, spicy, anise, etc.)
ChemCom has identified multiple hORs activated by the most important Key Malodorant Compounds (KMMs), including body malodors (sweat) also other typical malodors (e.g. mildew, animal, fishy, sulfurous, beverage and food off-notes, etc.)
Same hORs activated by 2 different agonists
Enhancer
Enhancers can intensify the perception compounds that allows the use of less materials to achieve the same level of perception. Besides saving materials, and thus the costs of using them, they also make it possible to reduce the concentrations of some compounds that have dosage restrictions on the market due to biodegradability, safety, or allergenic reasons. Those specific enhancers can allow for news usages of expensive materials in cheap applications.
ChemCom has already identified several enhancers on different hORs which have a proven efficacy in in vitro assays (by classically adding a fixed concentration of agonist to escalading doses of enhancer, and vice et versa, see graphs below). Human efficacy assessment is currently ongoing.
Enhancement of an activated hORs by one compound (enhancer)
Enhancer at variable concentrations + Agonist at a fixed concentration [-4.5]
Enhancer alone at variable concentrations
Agonist at variable concentrations + Enhancer at a fixed concentration [-4.5]
Agonist at variable concentrations + Enhancer at a fixed concentration [-5.0]
Agonist at variable concentrations + Enhancer at a fixed concentration [-5.5]
Agonist alone at variable concentrations
Antagonist
The possibility of selectively blocking the perception of a malodor without affecting the remaining olfactory landscape has emerged as a new concept in the aftermath of the discovery of Olfactory Receptors (ORs) (Buck et al., 1991) and the ensuing combinatorial theory of olfaction (Malnic et al., 2000). Indeed, it has been learned from this pioneering research that the perceptual recognition of an odorant relies first on its selective interaction with at least one but more likely several ORs.
It can therefore be assumed that selectively blocking one or more of the ORs involved in the recognition of the odorant with an antagonist will result in a modification of the coding and therefore of the perception.
ChemCom has already identified several antagonists of malodors which have demonstrated their efficacy in human sensory assays (mildew/earthy, sweat).